Measuring the placenta is easy and noninvasive with Estimated Placental Volume (EPV).
Of the current ways to measure and monitor the placenta, Estimated Placental Volume (EPV) is the most ready for clinical implementation due to its ease to perform via a standard 2D ultrasound during prenatal care.
Three simple measurements taken during a standard prenatal ultrasound produce an Estimated Placental Volume (EPV), which is then input into an app that then outputs measurements against the normative curves of size for gestational age.
The health care provider measures the placenta’s width, height, and thickness. EPV measurements can begin at 20 weeks and continue every 3-4 weeks, similar to fetal growth scans.
The app displays the Estimated Placental Volume in cc units, relative to the range for a baby’s gestational age, highlighting whether the measurement is within the standard range, below 10th percentile or above 90th percentile.
Providers: EPV video tutorials ● Guide and manual
Further questions on how to implement EPV can be directed to Dr. Harvey Kliman, who, with his father, mathematician and engineer Merwin Kliman, created the Estimated Placental Volume equation. EPV enables a 3D curved object (a placenta) to be measured in 2D. The complex polynomial uses width, height and thickness to calculate the volume of a spherical cap from an imaginary cross-section through the middle of the cap.
Measure the Placenta with
Merwin’s EPV Calculator
The app calculates the volume of a spherical cap, placed against a normative curve for placenta size by gestational age.
No smartphone? Use the simple EPV Web Calculator.
Another app, Merwins Desktop Calculator, enables calculation of EPV and sharing, printing, etc., from a Mac desktop computer. Useful for a doctor's office.
Published peer-reviewed validation:
“Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling.” Azpurua HJ, Funai EF, Coraluzzi L, Sasson I, Doherty L, Kliman M, Kliman HJ. Am J Perinatology, 27: 151-155, 2010. (Link - free full PDF)
“Utilizing 2-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume (EPV).” Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Am J Perinatology. 2013 Oct 9. [Link - Epub ahead of print]
“Estimated placental volume and gestational age.” Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Roberts AE, Kliman HJ. (2018) American Journal of Perinatology, 35:748-57, 2018; doi: 10.1055/s-0037-1615285. (Link - free full PDF)
Dr. Ann O'Neill shares her personal story of the loss of her fourth son on his due date, after which Dr. Harvey Kliman talks about how Estimated Placental Volume (EPV) could have saved Ann's son's life. This presentation was part of the Placental Consortium Webinar Series through Australia's University of Queensland Stillbirth Centre of Research Excellence presented on November 15, 2023.